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Information about p27/Kip1B phospho-Tyr187 CDKN1B Polyclonal Antibody

Immunogne:Rabbit polyclonal antibody raised against synthetic phosphopeptides of CDKN1B.
Description:p27/Kip1B phospho-Tyr187 CDKN1B Polyclonal Antibody encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of p27/Kip1B phospho-Tyr187 CDKN1B Polyclonal Antibody, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state.