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Properties about p27/Kip1B (phospho-Tyr157) (CDKN1B) Polyclonal Antibody

Applications:IHC-P, WB-Ce
Immunogne:Rabbit polyclonal antibody raised against synthetic phosphopeptides of CDKN1B.
p27/Kip1B (phospho-Tyr157) (CDKN1B) Polyclonal Antibody encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, p27/Kip1B (phospho-Tyr157) (CDKN1B) Polyclonal Antibody is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state.