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Information of Terlipressin Acetate

Terlipressin (trade names Teripress by New Medicon Pharma and Glypressin by Ferring Pharmaceuticals) is an analogue of vasopressin used as a vasoactive drug in the management of hypotension. It has been found to be effective when norepinephrine does not help.
Indications for use include norepinephrine-resistant septic shock and hepatorenal syndrome. In addition, it is used in bleeding esophageal varices.
Item Name  Terlipressin Acetate  
Cas No.   14636-12-5 
Molecular Formula   C52H74N16O15S2 
Molecular Weight   1227.37
Information of Terlipressin Acetate:
Purity (HPLC)  98.0%min. 
Appearance   White powder 
Single Impurity (HPLC)   1.0%max 
Amino Acid Composition   ±10% of theoretical 
Peptide Content (N%)   ≥80.0%  
Water Content(Karl Fischer)   ≤10.0% 
Specific Rotation (20/D)      -95.0~-105.0°(c=1 1%HAc) 
Acetate Content (HPIC)  ≤15.0% 
MS(ESI)  Consistent 
Mass Balance   95.0~105.0%