Knowledg About Dynorphin A(1-13) Acetate
Item Name Dynorphin A(1-13) Acetate
Molecular Formula C75H126N24O15
CAS No. 72957-38-1
Dynorphins Peptides for Cell Biology; Dynorphins; Neuropeptides; Opioid Peptides; Opioid receptor and opioid-like receptor
Dynorphins exert their effects primarily through the κ-opioid receptor (KOR), a G-protein-coupled receptor. Two subtypes of KORs have been identified: K1 and K2. Although KOR is the primary receptor for all dynorphins, the peptides do have some affinity for the μ-opioid receptor (MOR), δ-opioid receptor (DOR), N-methyl-D-aspartic acid (NMDA)-type glutamate receptor. Different dynorphins show different receptor selectivities and potencies at receptors. Big dynorphin and dynorphin A have the same selectivity for human KOR, but dynorphin A is more selective for KOR over MOR and DOR than is big dynorphin. Big dynorphin is more potent at KORs than is dynorphin A. Both big dynorphin and dynorphin A are more potent and more selective than dynorphin B.