Properties of Atosiban Acetate
Molecular Formula: C43H67N11O12S2
CAS No.: 90779-69-4
Properties of Atosiban Acetate:
Appearance :White powder
Specific Optical Rotation (c=1,1%HAc) :-45.0~-55.0°
Water Content(Karl Fischer) :≤5.0%
Acetate Content(by HPLC) :≤15.0%
Amino Acid Composition :±10% of theoretical
Purity (by HPLC) :≥98.0%
Single Impurity(by HPLC) :≤1.0%
Peptide Content(by %N) :≥80%
Assay(By Anhydrous, Acetic Acid-free ) :95.0~105.0%
Bacterial Endotoxins :≤5EU/mg
Chemically, atosiban is a modified form of oxytocin that inhibits the action of this hormone on the uterus, leading to a cessation of contractions.
A 2005 systematic review by the Cochrane Collaboration showed that while atosiban had fewer side-effects than alternative drugs (such as ritodrine), it was no better than placebo in the major outcomes, and in one study showed worse neonatal outcomes. The reviewers suggest nifedipine may be more promising.